Publications

 

Poster: Plasma profiling reveals novel biomarkers for drug-induced liver injury in humans  13th Human Proteome Organization World Congress, Madrid, 5-8 October 2014   
Publication: Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury  Gastroenterology 2014 Jul;147(1):109-118. PMID: 24704526
Presentation: Qualification of clinical safety biomarkers Lessons learned from the IMI SAFE-T consortium Exploratory Clinical Development World, London (UK), 3-5 June 2014 
Presentation: Clinical biomarker qualification for drug-induced injury to kidney, liver and the vascular system within the Innovative Medicines Initiative (IMI) project SAFE-T  Microsomes and Drug Oxidation meeting, Stuttgart (Germany), 19 May 2014
Poster: Analysis of the hepatoproteome during repeat acetaminophen exposure reveals novel processes associated with the adaptation of the liver to chemical insult  BTS Annual Congress, London, 28-29 April 2014
Publication: Translation Strategy for the Qualification of Drug-induced Vascular Injury Biomarkers  Toxicol Pathol. 2014 Apr 24;42(4):658-671
Publication: Aspirin but not Meloxicam Attenuates Early Atherosclerosis in Apolipoprotein E Knockout Mice Israel Medical Association Journal, vol.16, April 2014
Presentation: Biomarker Qualification for Drug-Induced Injury to Kidney, Liver and the Vascular System within IMI SAFE-T Project   DIA 26th Annual EuroMeeting, Vienna (Austria), 25-27 March 2014 
Poster: Clinical performance of translatable biomarkers for drug-induced vascular injury  Society of Toxicology Annual Meeting, Phoenix (AZ), 24 March 2014
Presentation: The European IMI SAFE-T Consortium: Progress and Challenges  FDA/C-Path DILI Conference XIV, 2014, Hyattsville, MD, 19 March 2014 
Publication: Absolute quantification of podocin, a potential biomarker of glomerular injury in human urine, by Liquid Chromatography - Multiple Reaction Monitoring cubed Mass spectrometry  J Pharm Biomed Anal. 2014 Jun;94:84-91.
Presentation: Progress in the search for new safety biomarkers  34th Annual European Meeting of the Toxicology Forum, Brussels, 23 October 2013 
Publication: Optimization of liquid chromatography–multiple reaction monitoring cubed mass spectrometry assay for protein quantification: Application to aquaporin-2 water channel in human urine  Journal of Chromatography A, Volume 1301, 2 August 2013, Pages 122–130
Publication: Assessment of emerging biomarkers of liver injury in human subjects  Toxicol Sci. 2013 Apr;132(2):276-83
Poster: Circulating MPs show a prothrombotic phenotype in patients  Circulating MPs show a prothrombotic phenotype in patients with long-life exposure to high LDL levels and directly associate with lipid-rich atherosclerotic plaque burden ICCC-_ISTH2013-56472_133265.pdf

Poster: 

The discovery of better biomarkers of drug induced liver injury (DILI) needs to use other endpoints than ALT. A pilot proof of concept study

Poster_DILI_EASL_2013_Final.pdf
Poster: A Collaborative Approach for the Qualification of Novel Kidney Biomarkers with the Regulatory Authorities ASN_Renal_Week_2012_SafeT_FINAL.pdf
Article: Real Time Identification of Drug-Induced Liver Injury (DILI) through Daily Screening of ALT Results: A Prospective Pilot Cohort Study  Plos one. August 2012 | Volume 7 | Issue 8 | e42418
Presentation: Clinical biomarker qualification for drug-induced injury to kidney, liver and the vascular system within SAFE-T 19th International Symposium on Microsomes and Drug Oxidations and 12th European ISSX Meeting . June 17-21, 2012 - Netherlands

Presentation: Safety Biomarkers: Opportunities and challenges in drug discovery and development

Presentation: IMI project - SAFE-T - An European consortium approach to renal safety biomarkers

EUROTOX 2012. June 17-20, 2012 - Stockholm
Presentation: IMI project - SAFE-T - An European consortium approach to renal safety biomarkers European Renal Association & European Dialysis and Transplant Association: 2012 annual conference. May 24th, 2012 - Paris
Presentation: Immunoassays in Multiplex for Personalized Medicine Molecular Diagnostics Europe, May  10-11, 2012 - London England
Presentation: Qualification of clinical biomarkers of DILI: Current gaps, research efforts, and future directions Society of Toxicology Annual Meeting, March 11 -15, 2012 - San Francisco, CA
Presentation: Development of Biomarkers and Translation Strategy for Drug-Induced Vascular Injury PSTC-FDA Workshop - January 31, 2012
Poster: The SAFE-T Consortium: A Collaborative Approach for the Qualification of Novel Kidney Biomarkers with the Regulatory Authorities  - J. Keenan, R. Schindler, P.Murray and the other members of the SAFE-T Consortium Work-package 2 American Society of Nephrology (ASN) - Kidney week 2011. November 8-13, 2011 - Philadelphia, Pennsylvania
Poster: "Histological comparisons of clinical and non-clinical of drug-induced vascular injury to support qualification of translational biomarkers" 30th Annual Symposium of Society of Toxicologic Pathology; 19-23 June 2011, Denver, USA
Presentation: "New translational biomarkers for drug-induced organ injury - the IMI SAFE-T project" Drug Development Summit; 8-9 June 2011, Zürich, Switzerland
Article: "A generic operational strategy to qualify translational safety biomarkers" Drug Discovery Today, in Press, available online 6 May 2011
Poster: "SAFE-T: A consortium for the regulatory qualification of human kidney biomarkers to monitor drug-induced kidney injury" World Congress of Nephrology; 8-12 April 2011, Vancouver, Canada
Presentation: "SAFE-T: testimonial from an industry partner (AZ)" IMI Info Day; 17 November 2010, Brussels
"The SAFE-T Consortium Qualification of Translational Biomarkers for the Kidney, Liver and Vascular System" Biomarker World Congress; 4-6 May 2010 Philadelphia, USA.

“Managing Drug Safety”

International Clinical Trials (ICT), February 2010, pp 64-66

"The European IMI SAFE-T Consortium: Qualification of translational safety biomarkers"

Toxicology Letters, Volume 189, Supplement 1, 13 September 2009, Page S157

SAFE-T Poster presented at Eurotox 2009

Safe-t EuroTOX Poster